4-Amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide → HCID 11997324, compound

HRID 900904Notes

Reaction equation

HRID 900904 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]3[N:24]=[CH:25][C:26]([C:27](O)=[O:28])=[C:16]3[N:15]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].[OH:30][CH2:31][C:32]([NH:35][S:36]([C:39]1[S:40][C:41]([Cl:45])=[C:42]([NH2:44])[CH:43]=1)(=[O:38])=[O:37])([CH3:34])[CH3:33]>>[Cl:45][C:41]1[S:40][C:39]([S:36](=[O:38])(=[O:37])[NH:35][C:32]([CH3:34])([CH3:33])[CH2:31][OH:30])=[CH:43][C:42]=1[NH:44][C:27]([C:26]1[CH:25]=[N:24][N:17]2[C:18]([C:20]([F:21])([F:22])[F:23])=[CH:19][C:14]([C:6]3[CH:7]=[CH:8][C:9]([C:10]([F:13])([F:12])[F:11])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=3)=[N:15][C:16]=12)=[O:28]

Participants

3

Reactant 2

HCID 672187574-Amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amideHCID 866071135-(3-Ethoxy-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11997324HCID 11997324, compound

Procedure

The title compound was prepared from 5-(3-ethoxy-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.10) and 4-amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.2) according to general procedure II. Yellow solid. MS (ISP) 684.3 [(M−H)−]; mp 234° C.

Sources & evidence

ORD record
ord-99ab86edbbab449ba4372894d38772fb
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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