4-Amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide → HCID 11997326, compound

HRID 900906Notes

Reaction equation

[F:1][C:2]([F:32])([F:31])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:18]3[N:25]=[CH:26][C:27]([C:28](O)=[O:29])=[C:17]3[N:16]=2)[CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12].[OH:33][CH2:34][C:35]([NH:38][S:39]([C:42]1[S:43][C:44]([Cl:48])=[C:45]([NH2:47])[CH:46]=1)(=[O:41])=[O:40])([CH3:37])[CH3:36]>>[Cl:48][C:44]1[S:43][C:42]([S:39](=[O:41])(=[O:40])[NH:38][C:35]([CH3:37])([CH3:36])[CH2:34][OH:33])=[CH:46][C:45]=1[NH:47][C:28]([C:27]1[CH:26]=[N:25][N:18]2[C:19]([C:21]([F:22])([F:24])[F:23])=[CH:20][C:15]([C:7]3[CH:8]=[CH:9][C:10]([C:11]([F:14])([F:13])[F:12])=[C:5]([O:4][CH2:3][C:2]([F:32])([F:31])[F:1])[CH:6]=3)=[N:16][C:17]=12)=[O:29]

Participants

Reactant 2

HCID 672187574-Amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

HCID 866071155-[3-(2,2,2-Trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11997326HCID 11997326, compound

Procedure

The title compound was prepared from 5-[3-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.10) and 4-amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.2) according to general procedure II.

Sources & evidence

ORD record: ord-cac78d689dfd41e29db2963afa4a2fa8
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07361659B2

Reaction notes

Loading…