HRID900911

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12

HCID66650268

未命名化合物

HCID67218481

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1cc(S(=O)(=O)NC(CO)CO)sc1Cl)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12

HCID86607117

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 4-amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide (example B.4) according to general procedure II. Light yellow solid. MS (ISP) 624.2 [(M−H)−]; mp 241° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a6329c1e906245bfbe5b2aa3ac9f8e60
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07361659B2
来源说明: uspto-grants-2008_04

反应 SMILES

[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[OH:26][CH2:27][CH:28]([NH:31][S:32]([C:35]1[S:36][C:37]([Cl:41])=[C:38]([NH2:40])[CH:39]=1)(=[O:34])=[O:33])[CH2:29][OH:30]>>[Cl:41][C:37]1[S:36][C:35]([S:32](=[O:34])(=[O:33])[NH:31][CH:28]([CH2:27][OH:26])[CH2:29][OH:30])=[CH:39][C:38]=1[NH:40][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([CH:2]([F:25])[F:1])=[CH:4][C:5]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)=[N:6][C:7]=12)=[O:14]