HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methyl-thiazole-5-sulfonic acid bis-(2-hydroxy-ethyl)-amide → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {5-[bis-(2-hydroxy-ethyl)-sulfamoyl]-4-methyl-thiazol-2-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methyl-thiazole-5-sulfonic acid bis-(2-hydroxy-ethyl)-amide | HCID 63945207 | — |
| Reactant | 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid | HCID 66650268 | — |
| Product | 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {5-[bis-(2-hydroxy-ethyl)-sulfamoyl]-4-methyl-thiazol-2-yl}-amide | HCID 11996261 | — |
Reaction Steps
The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C. 1) and 2-amino-4-methyl-thiazole-5-sulfonic acid bis-(2-hydroxy-ethyl)-amide (example B.8) according to general procedure II. Light yellow solid. MS (ISP) 621.1 [(M+H)+]; mp 191° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361659B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-a9110449652046c9ba0b20262c1cc973 |
| Source note | uspto-grants-2008_04 |