2-Amino-1,3-thiazole-5-sulfonamide → HCID 86607121, compound

HRID 900933Notes

Reaction equation

HRID 900933 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[NH2:27][C:28]1[S:29][C:30]([S:33]([NH2:36])(=[O:35])=[O:34])=[CH:31][N:32]=1>>[S:33]([C:30]1[S:29][C:28]([NH:27][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([C:2]([F:25])([F:1])[F:26])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:17][CH:16]=4)=[N:6][C:7]=23)=[O:14])=[N:32][CH:31]=1)(=[O:35])(=[O:34])[NH2:36]

Participants

3

Reactant 2

HCID 219574332-Amino-1,3-thiazole-5-sulfonamideHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 86607121HCID 86607121, compound

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 2-amino-thiazole-5-sulfonic acid amide [CAS-No. 63735-95-5] according to general procedure II. Yellow solid. MS (ISP) 535.2 [(M−H)−]; mp 309° C.

Sources & evidence

ORD record
ord-c2fed49b6d8446648a94922b854f99ba
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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