2-Amino-1,3-thiazole-5-sulfonamide → HCID 11996402, compound

HRID 900934Notes

Reaction equation

HRID 900934 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[NH2:26][C:27]1[S:28][C:29]([S:32]([NH2:35])(=[O:34])=[O:33])=[CH:30][N:31]=1>>[S:32]([C:29]1[S:28][C:27]([NH:26][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:25])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:24])[F:23])=[CH:17][CH:16]=4)=[N:6][C:7]=23)=[O:13])=[N:31][CH:30]=1)(=[O:34])(=[O:33])[NH2:35]

Participants

3

Reactant 2

HCID 219574332-Amino-1,3-thiazole-5-sulfonamideHCID 666502687-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11996402HCID 11996402, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C. 1) and 2-amino-thiazole-5-sulfonic acid amide [CAS-No. 63735-95-5] according to general procedure II. Light yellow solid. MS (ISP) 517.2 [(M−H)−]; mp 311° C.

Sources & evidence

ORD record
ord-41b1e6406f7a4b64a1ed32c36fe575c7
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

Loading…