HRID900935

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID86607101

未命名化合物

结构：CCOc1cc(-c2cc(C(F)(F)F)n3ncc(C(=O)O)c3n2)ccc1C(F)(F)F

HCID86607113

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(-c2cc(C(F)(F)F)n3ncc(C(=O)Nc4nc(C)c(S(=O)(=O)NC(C)(CO)CO)s4)c3n2)ccc1C(F)(F)F

HCID11996403

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 5-(3-ethoxy-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.10) and 2-amino-4-methyl-thiazole-5-sulfonic acid (2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-amide (example B.9) according to general procedure II. Light yellow solid. MS (ISP) 681.2 [(M−H)−]; mp 220° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9e7d7e507f344e1ea3e4ad688ae2e650
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07361659B2
来源说明: uspto-grants-2008_04

反应 SMILES

[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]3[N:24]=[CH:25][C:26]([C:27](O)=[O:28])=[C:16]3[N:15]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].[OH:30][CH2:31][C:32]([NH:36][S:37]([C:40]1[S:44][C:43]([NH2:45])=[N:42][C:41]=1[CH3:46])(=[O:39])=[O:38])([CH2:34][OH:35])[CH3:33]>>[OH:35][CH2:34][C:32]([NH:36][S:37]([C:40]1[S:44][C:43]([NH:45][C:27]([C:26]2[CH:25]=[N:24][N:17]3[C:18]([C:20]([F:23])([F:21])[F:22])=[CH:19][C:14]([C:6]4[CH:7]=[CH:8][C:9]([C:10]([F:11])([F:12])[F:13])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=4)=[N:15][C:16]=23)=[O:28])=[N:42][C:41]=1[CH3:46])(=[O:39])=[O:38])([CH2:31][OH:30])[CH3:33]