HRID900936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12

HCID66650268

未命名化合物

结构：CN(C)CCN(CCN(C)C)S(=O)(=O)c1cc([N+](=O)[O-])c(Cl)s1

HCID67218946

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCNS(=O)(=O)c1cc(NC(=O)c2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c(Cl)s1

HCID11997755

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C. 1) and 4-amino-5-chloro-thiophene-2-sulfonic acid (2-dimethylamino-ethyl)-amide (example B.14) according to general procedure II.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-357d41b8146144deb6beae8d2a529971
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07361659B2
来源说明: uspto-grants-2008_04

反应 SMILES

[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[CH3:26][N:27]([CH3:48])[CH2:28][CH2:29][N:30](CCN(C)C)[S:31]([C:34]1[S:35][C:36]([Cl:42])=[C:37]([N+:39]([O-])=O)[CH:38]=1)(=[O:33])=[O:32]>>[Cl:42][C:36]1[S:35][C:34]([S:31](=[O:33])(=[O:32])[NH:30][CH2:29][CH2:28][N:27]([CH3:48])[CH3:26])=[CH:38][C:37]=1[NH:39][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([CH:2]([F:25])[F:1])=[CH:4][C:5]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:19][CH:20]=3)=[N:6][C:7]=12)=[O:13]