HCID 67218946, compound → 7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [2-chloro-5-(2-dimethylamino-ethylsulfamoyl)-thiophen-3-yl]-amide

HRID 900937Notes

Reaction equation

HRID 900937 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[CH3:27][N:28]([CH3:49])[CH2:29][CH2:30][N:31](CCN(C)C)[S:32]([C:35]1[S:36][C:37]([Cl:43])=[C:38]([N+:40]([O-])=O)[CH:39]=1)(=[O:34])=[O:33]>>[Cl:43][C:37]1[S:36][C:35]([S:32](=[O:34])(=[O:33])[NH:31][CH2:30][CH2:29][N:28]([CH3:49])[CH3:27])=[CH:39][C:38]=1[NH:40][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([C:2]([F:1])([F:25])[F:26])=[CH:4][C:5]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:24])[F:23])=[CH:17][CH:16]=3)=[N:6][C:7]=12)=[O:13]

Participants

3

Reactant 2

HCID 67218946HCID 67218946, compoundHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 119977567-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [2-chloro-5-(2-dimethylamino-ethylsulfamoyl)-thiophen-3-yl]-amide

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 4-amino-5-chloro-thiophene-2-sulfonic acid (2-dimethylamino-ethyl)-amide (example B.14) according to general procedure II.

Sources & evidence

ORD record
ord-1c7fbd5006a24b788f083eeb4249686c
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

Loading…