7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → HCID 11997906, compound

HRID 900948Notes

Reaction equation

HRID 900948 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[Cl:26][C:27]1[S:31][C:30]([S:32]([N:35]2[CH2:39][CH2:38][CH:37]([OH:40])[CH2:36]2)(=[O:34])=[O:33])=[CH:29][C:28]=1[N+:41]([O-])=O>>[Cl:26][C:27]1[S:31][C:30]([S:32]([N:35]2[CH2:39][CH2:38][CH:37]([OH:40])[CH2:36]2)(=[O:34])=[O:33])=[CH:29][C:28]=1[NH:41][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([CH:2]([F:1])[F:25])=[CH:4][C:5]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:19][CH:20]=3)=[N:6][C:7]=12)=[O:14]

Participants

3

Reactant 2

HCID 666502687-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acidHCID 67218707HCID 67218707, compound

Product 1

HCID 11997906HCID 11997906, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and (RS)-1-(4-amino-5-chloro-thiophene-2-sulfonyl)-pyrrolidin-3-ol (example B.18) according to general procedure II. Yellow solid. MS (ISP) 622.2 [(M+H)+]; mp 274° C.

Sources & evidence

ORD record
ord-d48b58ac339640448b6cd58c8265e1ac
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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