HCID 67218707, compound → HCID 11997907, compound

HRID 900949Notes

Reaction equation

HRID 900949 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[Cl:27][C:28]1[S:32][C:31]([S:33]([N:36]2[CH2:40][CH2:39][CH:38]([OH:41])[CH2:37]2)(=[O:35])=[O:34])=[CH:30][C:29]=1[N+:42]([O-])=O>>[Cl:27][C:28]1[S:32][C:31]([S:33]([N:36]2[CH2:40][CH2:39][CH:38]([OH:41])[CH2:37]2)(=[O:35])=[O:34])=[CH:30][C:29]=1[NH:42][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([C:2]([F:26])([F:25])[F:1])=[CH:4][C:5]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=3)=[N:6][C:7]=12)=[O:13]

Participants

3

Reactant 2

HCID 67218707HCID 67218707, compoundHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11997907HCID 11997907, compound

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and (RS)-1-(4-amino-5-chloro-thiophene-2-sulfonyl)-pyrrolidin-3-ol-(example B.18) according to general procedure II. Yellow solid. MS (ISP) 640.2 [(M+H)+]; mp 270° C.

Sources & evidence

ORD record
ord-c0a39a1596b94d598ff4cae0ddb9ba24
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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