HRID900954

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)c1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12

HCID66650268

未命名化合物

结构：CN(CCO)S(=O)(=O)c1cc([N+](=O)[O-])c(Cl)s1

HCID67218500

未命名化合物

PRODUCTS

生成物

结构：CN(CCO)S(=O)(=O)c1cc(NC(=O)c2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c(Cl)s1

HCID11997908

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C. 1) and 4-amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-ethyl)-methyl-amide (example B.21) according to general procedure II.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-01d6c413b4e94cf589237dcf9158fff7
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07361659B2
来源说明: uspto-grants-2008_04

反应 SMILES

[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[OH:26][CH2:27][CH2:28][N:29]([CH3:42])[S:30]([C:33]1[S:34][C:35]([Cl:41])=[C:36]([N+:38]([O-])=O)[CH:37]=1)(=[O:32])=[O:31]>>[Cl:41][C:35]1[S:34][C:33]([S:30](=[O:32])(=[O:31])[N:29]([CH2:28][CH2:27][OH:26])[CH3:42])=[CH:37][C:36]=1[NH:38][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([CH:2]([F:1])[F:25])=[CH:4][C:5]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:20]=3)=[N:6][C:7]=12)=[O:14]