7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → HCID 11997908, compound

HRID 900954Notes

Reaction equation

HRID 900954 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[OH:26][CH2:27][CH2:28][N:29]([CH3:42])[S:30]([C:33]1[S:34][C:35]([Cl:41])=[C:36]([N+:38]([O-])=O)[CH:37]=1)(=[O:32])=[O:31]>>[Cl:41][C:35]1[S:34][C:33]([S:30](=[O:32])(=[O:31])[N:29]([CH2:28][CH2:27][OH:26])[CH3:42])=[CH:37][C:36]=1[NH:38][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([CH:2]([F:1])[F:25])=[CH:4][C:5]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:20]=3)=[N:6][C:7]=12)=[O:14]

Participants

3

Reactant 2

HCID 666502687-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acidHCID 67218500HCID 67218500, compound

Product 1

HCID 11997908HCID 11997908, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C. 1) and 4-amino-5-chloro-thiophene-2-sulfonic acid (2-hydroxy-ethyl)-methyl-amide (example B.21) according to general procedure II.

Sources & evidence

ORD record
ord-01d6c413b4e94cf589237dcf9158fff7
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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