HCID 67219086, compound → HCID 11995693, compound

HRID 900959Notes

Reaction equation

HRID 900959 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.C(OC(=O)[NH:33][CH2:34][CH2:35][NH:36][S:37]([C:40]1[S:41][C:42]([Cl:48])=[C:43]([N+:45]([O-])=O)[CH:44]=1)(=[O:39])=[O:38])(C)(C)C>>[NH2:33][CH2:34][CH2:35][NH:36][S:37]([C:40]1[S:41][C:42]([Cl:48])=[C:43]([NH:45][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([C:2]([F:26])([F:25])[F:1])=[CH:4][C:5]([C:15]4[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:19][CH:20]=4)=[N:6][C:7]=23)=[O:13])[CH:44]=1)(=[O:38])=[O:39]

Participants

3

Reactant 2

HCID 67219086HCID 67219086, compoundHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11995693HCID 11995693, compound

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and [2-(4-amino-5-chloro-thiophene-2-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester (example B.17) according to general procedure II and subsequent removal of the protecting group with trifluoroacetic acid in dichloromethane at 0° C. for 3 h. Yellow solid. MS (ISP) 611.0 [(M−H)−]; mp 195° C.

Workup

  1. customaccording to general procedure II and subsequent removal of the protecting group with trifluoroacetic acid in dichloromethane at 0° C. for 3 h

Sources & evidence

ORD record
ord-04084dcfc3764ce3a631f03b7e9b76cb
Source dataset
uspto-grants-2008_04
Patent number
US07361659B2

Reaction notes

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