[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → 4-chloro-N-{4-[2-(4-cyclohexylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide

Participants

Role	Name	HCID	Charge
Reactant	[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid	HCID 677042	—
Reactant	1-(Cyclohexylmethyl)piperazine	HCID 2735885	—
Product	4-chloro-N-{4-[2-(4-cyclohexylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide	HCID 59698855	—

Reaction Steps

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with (1-cyclohexyl-methyl)piperazine to give 4-chloro-N-{4-[2-(4-cyclohexylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide, using general procedure A. Colorless amorphous solid. MS 461.0 ([M+H]+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07361672B2
Source dataset	uspto-grants-2008_04
ORD ID	ord-663cdfeb4af74d278122d0e484d7af86
Source note	uspto-grants-2008_04