1-((Pyrrolidine-1-carbonyl)methyl)piperazine → HCID 42643068, compound

HRID 901000Notes

Reaction equation

HRID 901000 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([OH:17])=O)[N:13]=2)=[O:7])=[CH:4][CH:3]=1.[N:20]1([C:25]([CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15](=[O:17])[N:31]3[CH2:30][CH2:29][N:28]([CH2:27][C:25](=[O:26])[N:20]4[CH2:21][CH2:22][CH2:23][CH2:24]4)[CH2:33][CH2:32]3)[N:13]=2)=[O:7])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 1006141-((Pyrrolidine-1-carbonyl)methyl)piperazineHCID 677042[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid

Product 1

HCID 42643068HCID 42643068, compound

Procedure

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with 1-(pyrrolidinocarbonylmethyl)piperazine to give 4-chloro-N-(4-{2-oxo-2-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethyl}-thiazol-2-yl)-benzamide, using general procedure A. Off-white solid. MS 476.1 ([M+H]+)

Sources & evidence

ORD record
ord-0fd70a6f9c7547ef82cc70715c8c932f
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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