[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide

Participants

Role	Name	HCID	Charge
Reactant	[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid	HCID 677042	—
Reactant	N,N-dimethyl-2-(piperazin-1-yl)acetamide	HCID 2758642	—
Product	4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide	HCID 59698886	—

Reaction Steps

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with piperazino-acetic acid N,N-dimethylamide to give 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide, using general procedure A. Amorphous white solid. MS 450.0 ([M+H]+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07361672B2
Source dataset	uspto-grants-2008_04
ORD ID	ord-c85db3b31e494a0194d2e7e138c39184
Source note	uspto-grants-2008_04