[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → HCID 59698892, Verbindung

HRID 901004Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 901004
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([OH:17])=O)[N:13]=2)=[O:7])=[CH:4][CH:3]=1.[C:20]([NH:24][S:25]([C:28]1[C:29]([C:34]2[CH:39]=[CH:38][C:37]([NH2:40])=[C:36]([F:41])[CH:35]=2)=[CH:30][CH:31]=[CH:32][CH:33]=1)(=[O:27])=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[C:20]([NH:24][S:25]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[C:34]1[CH:39]=[CH:38][C:37]([NH:40][C:15]([CH2:14][C:12]2[N:13]=[C:9]([NH:8][C:6](=[O:7])[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:19][CH:18]=3)[S:10][CH:11]=2)=[O:17])=[C:36]([F:41])[CH:35]=1)(=[O:27])=[O:26])([CH3:23])([CH3:21])[CH3:22]

Komponenten

3

Edukt 2

HCID 677042[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acidHCID 108532844'-Amino-3'-fluoro-biphenyl-2-sulfonic acid tert-butylamide

Produkt 1

HCID 59698892HCID 59698892, Verbindung

Versuchsvorschrift

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with 4′-amino-3′-fluoro-biphenyl-2-sulfonic acid tert-butylamide (CAS 209919-51-7, prepared according to B.-Y. Zhu et al., patent application WO 2000071515) to give N-{4-[(2′-tert-butylsulfamoyl-3-fluoro-biphenyl-4-ylcarbamoyl)-methyl]-thiazol-2-yl}-4-chloro-benzamide, using general procedure C. White amorphous solid. MS 601.3 ([M+H]+)

Quellen und Nachweise

ORD-Eintrag
ord-cd36deb646c348efb9a50d7bf56bca62
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07361672B2

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