1-(1-Methyl-4-piperidinyl)piperazine → HCID 42643069, compound

HRID 901006Notes

Reaction equation

HRID 901006 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([OH:17])=O)[N:13]=2)=[O:7])=[CH:4][CH:3]=1.[CH3:20][N:21]1[CH2:26][CH2:25][CH:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([N:30]3[CH2:29][CH2:28][N:27]([CH:24]4[CH2:25][CH2:26][N:21]([CH3:20])[CH2:22][CH2:23]4)[CH2:32][CH2:31]3)=[O:17])[N:13]=2)=[O:7])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 5663241-(1-Methyl-4-piperidinyl)piperazineHCID 677042[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid

Product 1

HCID 42643069HCID 42643069, compound

Procedure

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with 1-(N-methylpiperidin-4-yl)piperazine to give 4-chloro-N-(4-{2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-benzamide, using general procedure C. Off-white solid. MS 462.3 ([M+H]+)

Sources & evidence

ORD record
ord-ef93610b76ae45cf9999505fb7d39776
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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