[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → HCID 59698853, compound

HRID 901007Notes

Reaction equation

HRID 901007 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15]([OH:17])=O)[N:13]=2)=[O:7])=[CH:4][CH:3]=1.Cl.[CH3:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]1[CH:32]=[CH:33][C:34]([NH2:37])=[N:35][CH:36]=1)(=[O:24])=[O:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15](=[O:17])[NH:37][C:34]3[CH:33]=[CH:32][C:31]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=4[S:22]([CH3:21])(=[O:24])=[O:23])=[CH:36][N:35]=3)[N:13]=2)=[O:7])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 677042[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acidHCID 18549506209959-31-9

Product 1

HCID 59698853HCID 59698853, compound

Procedure

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with 5-(2-methanesulfonyl-phenyl)-pyridin-2-ylamine, hydrochloride (CAS 209959-31-9) to give 4-chloro-N-(4-{[5-(2-methanesulfonyl-phenyl)-pyridin-2-ylcarbamoyl]-methyl}-thiazol-2-yl)-benzamide, using general procedure C. White solid. MS 527.2 ([M+H]+)

Sources & evidence

ORD record
ord-95a3404e8e474d1ba0c667594d1a2cb4
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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