HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-Methyl-4-piperidinyl)piperazine → (4-{2-[4-(1-Methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-Methyl-4-piperidinyl)piperazine | HCID 566324 | — |
| Reactant | 2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)acetic acid | HCID 15480006 | — |
| Product | (4-{2-[4-(1-Methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-carbamic acid tert-butyl ester | HCID 59698869 | — |
Reaction Steps
47.1 Using general method C, (2-tert-butoxycarbonylamino-thiazol-4-yl)-acetic acid (example 37.2) was coupled with 1-(N-methylpiperidin-4-yl)piperazine to give (4-{2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-carbamic acid tert-butyl ester. Off-white powder. MS 424.0 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361672B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-3bdfc4a1a4df431f9c782485b1f54a2f |
| Source note | uspto-grants-2008_04 |