1-Methyl-4-(piperidin-4-yl)piperazine → HCID 59698842, compound

HRID 901032Notes

Reaction equation

HRID 901032 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][C:10]2[S:11][CH:12]=[C:13]([CH2:15][C:16]([OH:18])=O)[N:14]=2)=[O:8])=[CH:4][CH:3]=1.[CH3:19][N:20]1[CH2:25][CH2:24][N:23]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH2:22][CH2:21]1>>[CH3:19][N:20]1[CH2:25][CH2:24][N:23]([CH:26]2[CH2:31][CH2:30][N:29]([C:16](=[O:18])[CH2:15][C:13]3[N:14]=[C:10]([NH:9][C:7]([C:5]4[S:6][C:2]([Cl:1])=[CH:3][CH:4]=4)=[O:8])[S:11][CH:12]=3)[CH2:28][CH2:27]2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 7957071-Methyl-4-(piperidin-4-yl)piperazineHCID 42643067HCID 42643067, compound

Product 1

HCID 59698842HCID 59698842, compound

Procedure

53.2 Using general method A, {2-[(5-chloro-thiophene-2-carbonyl)-amino]-thiazol-4-yl}-acetic acid was coupled with 1-methyl-4-(piperidin-4-yl)-piperazine to give 5-chloro-thiophene-2-carboxylic acid (4-{2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-amide. Light yellow amorphous solid. MS 468.4 ([M+H]+)

Sources & evidence

ORD record
ord-b5f9eeed5b14483595b80935ff776ab3
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

Loading…