2-(2-Oxopyrrolidin-1-yl)acetic acid → HCID 59698833, compound

HRID 901034Notes

Reaction equation

HRID 901034 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15](=[O:22])[N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[N:13]=2)=[O:7])=[CH:4][CH:3]=1.[O:25]=[C:26]1[CH2:30][CH2:29][CH2:28][N:27]1[CH2:31][C:32](O)=[O:33]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][C:15](=[O:22])[N:16]3[CH2:17][CH2:18][N:19]([C:32](=[O:33])[CH2:31][N:27]4[CH2:28][CH2:29][CH2:30][C:26]4=[O:25])[CH2:20][CH2:21]3)[N:13]=2)=[O:7])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 31466872-(2-Oxopyrrolidin-1-yl)acetic acidHCID 59698846HCID 59698846, compound

Product 1

HCID 59698833HCID 59698833, compound

Procedure

54.3 Using general procedure A, 4-chloro-N-[4-(2-oxo-2-piperazin-1-yl-ethyl)-thiazol-2-yl]-benzamide was coupled with (2-oxo-pyrrolidine-1-yl)-acetic acid (CAS 53934-76-2) to give 4-chloro-N-[4-(2-oxo-2-{4-[2-(2-oxo-pyrrolidin-1-yl)-acetyl]-piperazin-1-yl}-ethyl)-thiazol-2-yl]-benzamide. White solid. MS 490.4 ([M+H]+)

Sources & evidence

ORD record
ord-231e0b4d788248d5a47c5aac6a0ed6dd
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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