HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzoic Acid → [3-(4-Chloro-benzoylamino)-pyrazol-1-yl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzoic Acid | HCID 6318 | — |
| Reactant | ethyl 2-(3-amino-1H-pyrazol-1-yl)acetate | HCID 5200378 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [3-(4-Chloro-benzoylamino)-pyrazol-1-yl]-acetic acid ethyl ester | HCID 59698863 | — |
Reaction Steps
59.1 Using general method A, with THF instead of DMF as solvent, (3-amino-pyrazol-1-yl)-acetic acid ethyl ester (example 57.1) was coupled with 4-chlorobenzoic acid to give [3-(4-chloro-benzoylamino)-pyrazol-1-yl]-acetic acid ethyl ester. Off-white solid. MS 308.3 ([M+H]+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361672B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-53f237f361c24571b854d06a1a297658 |
| Source note | uspto-grants-2008_04 |