1-(4-Amino-3-fluorophenyl)pyridin-2-one → HCID 59698862, compound

HRID 901043Notes

Reaction equation

HRID 901043 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][C:9]2[CH:13]=[CH:12][N:11]([CH2:14][C:15]([OH:17])=O)[N:10]=2)=[O:7])=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]2=[O:33])=[CH:23][C:22]=1[F:34]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[CH:13]=[CH:12][N:11]([CH2:14][C:15](=[O:17])[NH:20][C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]4=[O:33])=[CH:23][C:22]=3[F:34])[N:10]=2)=[O:7])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 221815481-(4-Amino-3-fluorophenyl)pyridin-2-oneHCID 59698879HCID 59698879, compound

Product 1

HCID 59698862HCID 59698862, compound

Procedure

59.3 According to general method B, [3-(4-chloro-benzoylamino)-pyrazol-1-yl]-acetic acid was reacted with 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one (CAS 536747-52-1, prepared according to C. F. Bigge et al., patent application WO 2003045912) to give 4-chloro-N-(1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-1H-pyrazol-3-yl)-benzamide. White solid. MS 466.3 ([M+H]+)

Sources & evidence

ORD record
ord-d79d24819c834088a0c327bcc53dc0f3
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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