5-Chloro-2-thiophenecarboxylic acid → HCID 42643126, compound

HRID 901046Notes

Reaction equation

HRID 901046 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][N:6]1[CH:10]=[N:9][C:8]([NH2:11])=[N:7]1)[CH3:2].[Cl:13][C:14]1[S:18][C:17]([C:19](O)=[O:20])=[CH:16][CH:15]=1>>[CH2:1]([O:3][C:4](=[O:12])[CH2:5][N:6]1[CH:10]=[N:9][C:8]([NH:11][C:19]([C:17]2[S:18][C:14]([Cl:13])=[CH:15][CH:16]=2)=[O:20])=[N:7]1)[CH3:2]

Participants

3

Reactant 2

HCID 950485-Chloro-2-thiophenecarboxylic acidHCID 42643123895571-94-5

Product 1

HCID 42643126HCID 42643126, compound

Procedure

61.2 Using general method A, (3-amino-[1,2,4]triazol-1-yl)-acetic acid ethyl ester was coupled with 5-chlorothiophene-2-carboxylic acid to give {3-[(5-chloro-thiophene-2-carbonyl)-amino]-[1,2,4]triazol-1-yl}-acetic acid ethyl ester. Off-white solid. MS 315.1 ([M+H]+)

Sources & evidence

ORD record
ord-1fdbeaccaed7445da20dee0eb7596a82
Source dataset
uspto-grants-2008_04
Patent number
US07361672B2

Reaction notes

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