Carbon tetrabromide → HCID 12992882, compound

Participants

Reaction Steps

In 40 ml of dichloromethane was dissolved 855 mg (1.8 mmol) of 2,6-dichloro-N-(2,6-dichlorobenzoyl)-N-(5-hydroxymethylpyrid-2-yl)benzamide (e), and 905 mg (2.7 mmol) of carbon tetrabromide and 573 mg (2.2 mmol) of triphenylphosphine were added. The mixture was stirred for 2.5 hours, and treated with a saturated sodium hydrogen carbonate aqueous solution. The mixture was subjected to extraction with chloroform, and the extract was washed with a saturated sodium chloride aqueous solution. The solvent was evaporated off under vacuum, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate (volume ratio)=3:1-2:1) to give 631 mg (yield 65%) of 2,6-dichloro-N-(5-bromomethylpyrid-2-yl)-N-(2,6-dichlorobenzoyl)benzamide (f).

Provenance & Evidence