Toluene → HCID 86608894, compound

Participants

Reaction Steps

In a 100 ml three necked flask equipped with a stir bar, thermocouple and a reflux condenser with a nitrogen inlet was dissolved triphenylphosphine (11.80 g, 45 mmol) in toluene (25 ml), ethyl-5-bromovalerate (12.54 g, 60 mmol) was added to the solution and the reaction mixture was refluxed for 2 hours and then cooled to room temperature. The toluene was decanted away from the oily solid and the residue was slurried in hexane (100 ml). The hexane (3×100 ml) was decanted away three times from the oily residue and oily residue was heated on a Kugelrohr apparatus at 40° C., 0.1 torr for 30 minutes to afford 19.0 g (89.6%) of the title compound.

Provenance & Evidence