Hydrochloric Acid → HCID 59699472, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6N HCl (30 ml, 5.5 eq ) was added to a solution of 16 (12.0 g) in 200 ml of MeOH at room temperature, and the reaction mixture was warmed up to 40° C. overnight. Methanol was removed in vacuo. The reaction mixture was washed with diethyl ether (50 ml×2). The aqueous solution was neutralized with 2N NaOH and extracted with ethyl acetate (100 ml×3). The organic layer was washed with brine, dried over sodium sulfate, and concentrated to provide the pure desired product (7.6 g).

Provenance & Evidence