HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydroxyindole-2-carboxylic acid → 1,2,3,4-Tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydroxyindole-2-carboxylic acid | HCID 88958 | — |
| Reactant | HCID 69282708 | HCID 69282708 | — |
| Product | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
Reaction Steps
According to the procedure described for the synthesis of Example 1/step 1 (3,4-dihydro-1H-isoquinolin-2-yl)-(5-hydroxy-1H-indol-2-yl)-methanone was synthesized from 5-hydroxy-indole-2-carboxylic acid and 1,2,3,4-tetrahydro-isoquinoline which was yielded in 72% as white solid. MS (m/e): 293.0 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07361682B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-8895543feecd4bfebcc7114a86af1fa3 |
| Source note | uspto-grants-2008_04 |