Methanol → 5-(1-isopropyl-pyrrolidin-3-yloxy)-1H-indole-2-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.05 g (6 mmol) 5-(1-Isopropyl-pyrrolidin-3-yloxy)-1H-indole-2-carboxylic acid ethyl ester and 0.299 g (7 mmol) lithiumhydroxide monohydrate 30 ml THF, 30 ml methanol and 15 ml water was heated to 100° C. for 2 h. The organic solvents were removed and aq. 1N HCl was added to adjust the pH of the solution to 2-3. Subsequently, the mixture was evaporated to dryness and the mixture was used without further purification in the next step. MS (m/e): 289.1 (MH+, 100%).

Provenance & Evidence