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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 901090Generated: October 25, 2026

1-Isopropylpiperidin-4-ol → 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/901090

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Isopropylpiperidin-4-olHCID 79681—
ReactantEthyl 5-hydroxy-1H-indole-2-carboxylateHCID 90677—
Reactant5-(1-Isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid ethyl esterHCID 44185246—
Product5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acidHCID 59699456—

Reaction Steps

According to the procedure described for the synthesis of Example 5/step 1 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid ethyl ester was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (commercially available) and 1-isopropyl-piperidin-4-ol (commercially available). The title compound was yielded in 33% as off-white solid. MS (m/e): 331.1 (MH+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07361682B2
Source datasetuspto-grants-2008_04
ORD IDord-3107c198f75b46f3b75c499866bceb56
Source noteuspto-grants-2008_04