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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 901091Generated: October 25, 2026

Ethyl 5-hydroxy-1H-indole-2-carboxylate → 5-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid

https://huagongshe.com/reaction/901091

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 5-hydroxy-1H-indole-2-carboxylateHCID 90677—
Reactant1-Methyl-2-pyrrolidineethanolHCID 93363—
Reactant5-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl esterHCID 69283274—
Product5-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acidHCID 59699458—

Reaction Steps

According to the procedure described for the synthesis of Example 5/step 1 5-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl ester was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (commercially available) and 2-(1-methyl-pyrrolidin-2-yl)-ethanol (commercially available). The title compound was yielded in 38% as light brown foam. MS (m/e): 317.1 (MH+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07361682B2
Source datasetuspto-grants-2008_04
ORD IDord-d2a1405bff534b2d9435c2d5b0cbac55
Source noteuspto-grants-2008_04