HCID 69283221, compound → HCID 69282983, compound

Participants

Reaction Steps

A mixture of 4.6 (0.016 mol) [5-((S)-1-Benzyl-pyrrolidin-3-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone and 480 mg of 10% palladium on charcoal in 250 ml ethyl actetate/acetic acid 9/1 was hydrogenated at room temperature during 4 h. After filtration the filtrate was evaporated to dryness and the residue was taken up in 250 ml DCM and 150 ml 10% Na2CO3. The aqueous phase was extracted with 2×100 ml DCM and the combined organic phases were dried with Na2SO4 and evaporated to dryness to yield 2.77 g (77% of the title compound as off white solid. MS (m/e): 316.1 (MH+, 100%).

Provenance & Evidence