反应详情

Phosphorous tribromide (2 mL) was added to a solution of (4-benzyloxy-3-chloro-phenyl)-methanol (CAB02127, 3.40 g, 13.7 mmol) in dichloromethane (50 mL) at 0° C. The mixture was stirred at this temperature for 1 h, diluted with diethyl ether (100 mL), transferred into a separation funnel and washed with water (50 mL) and brine (50 mL). The organic layer was dried over magnesium sulphate and concentrated under reduced pressure to give a white, analytical pure solid. Yield: 4.27 g (100%).

1. customtransferred into a separation funnel
2. washwashed with water (50 mL) and brine (50 mL)
3. dry with materialThe organic layer was dried over magnesium sulphate
4. concentrationconcentrated under reduced pressure
5. customto give a white, analytical pure solid