Iodine → HCID 178462348, compound

HRID 901196Notes

Reaction equation

HRID 901196 reaction equation
II.[CH3:3][CH:4]([OH:19])[CH:5]([OH:18])[C:6]1[N:11]=[C:10]2[C:12]([N:14]=[C:15]([NH2:17])[NH:16][C:9]2=[N:8][CH:7]=1)=[O:13]>>[CH3:3][C@H:4]([OH:19])[C@H:5]([OH:18])[C:6]1[N:11]=[C:10]2[C:12]([N:14]=[C:15]([NH2:17])[NH:16][C:9]2=[N:8][CH:7]=1)=[O:13]

Participants

3

Reactant 2

HCID 807IodineHCID 178469705HCID 178469705, compound

Product 1

HCID 178462348HCID 178462348, compound

Procedure

The resultant phenylhydrazone compound is reacted with an acetylating agent in pyridine to obtain a triacetylated compound, which is then condensed and cyclized with 6-hydroxy-2,4,5-triaminopyrimidine (TAU) in the coexistence of sodium acetate to obtain a biopterin derivative. After oxidized with iodine or other oxidizing agent, the biopterin derivative is subjected to deacetylation (hydrolysis) to produce L-biopterin.

Sources & evidence

ORD record
ord-46daa14c952c44a9aedea71ccb1095ec
Source dataset
uspto-grants-2008_04
Patent number
US07361759B2

Reaction notes

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