Hydrochloric Acid → HCID 178524411, compound

Participants

Reaction Steps

Sodium hypochlorite (14% available chlorine, 35 mL, 82.21 mmol) solution was added to a stirred solution of 2-hydroxynicotinic acid (7 g, 50.3 mmol) in 10% aqueous NaOH solution. The solution was stirred for 48 h at room temperature. An aqueous solution of sodium sulfite (3.150 g, 25 mmol) was added and further stirred for 30 min at room temperature. The solution was diluted by cold water and pH was adjusted to 2 by cold dilute HCl. The solids formed were filtered, washed by cold water and dried to yield 6.8 g (78%) of 5-chloro-2-hydroxy-nicotinic acid (70) as white solids. MP: 276° C.; 1H-NMR (DMSO-d6): δ 8.23 (d, J=2.8 Hz, 1H), 8.29 (d, J=2.8 Hz, 1H); EIMS: 174 (M+1).

Provenance & Evidence