Benzyl Bromide → 1-Benzyl-6-fluoro-4-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-oxo-1,2-dihydro-[1,8]-naphthyridine-3-carboxylic Acid Ethyl Ester

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Reaction Steps

This compound was prepared from 6-fluoro-4-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-oxo-1,2-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester (81) and benzyl bromide according to General Procedure B. Yield 391 mg (47%), MP 119° C.; 1H-NMR (DMSO-d6): δ 1.27 (t, J=7.2 Hz, 3H), 3.15 (m, 4H), 3.92 (m, 4H), 4.29 (q, J=7.2 Hz, 2H), 5.54 (s, 2H), 6.65 (dd, J=1.6, 3.2, Hz, 1H), 7.05 (d, J=3.6 Hz, 1H), 7.20 (m, 5H), 7.87 (d, J=3.2 Hz, 1H), 8.18 (dd, J=2.8, 8.8 Hz, 1H), 8.74 (d, J=2.8 Hz, 1H); EIMS: 505 (M+1). Anal. (C27H25FN4O5) C, H, N.

Provenance & Evidence