3-Fluorobenzyl bromide → HCID 59699639, compound

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Reaction Steps

This compound was prepared from 6-fluoro-6-chloro-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-2-oxo-1,2-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester (82) and 3-fluorobenzyl bromide according to General Procedure B. Yield 207 mg (37%), MP 186° C.; 1H-NMR (DMSO-d6): δ 1.28 (t, J=7.2 Hz, 3H), 3.16 (m, 4H), 3.92 (m, 4H), 4.32 (q, J=7.2 Hz, 2H), 5.24 (s, 2H), 7.07 (m, 3H), 7.15 (dd, J=3.6, 5.2 Hz, 1H), 7.30 (m, 1H), 7.47 (dd, J=1.2, 3.6 Hz, 1H), 7.80 (d, J=4.8 Hz, 1H), 8.29 (d, J=2.8 Hz, 1H), 8.73 (d, J=2.8 Hz, 1H); EIMS: 555 (M+1). Anal. (C27H24ClFN4O4S) C, H, N.

Provenance & Evidence