Phenacyl bromide → HCID 59699568, compound

Participants

Reaction Steps

This compound was prepared from 6-chloro-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-2-oxo-1,2-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester (82) and 2-bromoacetophenone according to General Procedure B. Yield 333 mg (59%), MP 227° C.; 1H-NMR (DMSO-d6): δ 1.29 (t, J=7.2 Hz, 3H), 3.20 (m, 4H), 3.92 (m, 4H), 4.32 (q, J=7.2 Hz, 2H), 5.87 (s, 2H), 7.17 (dd, J=3.6, 4.8 Hz, 1H), 7.48 (dd, J=1.2, 3.6 Hz, 1H), 7.61 (m, 2H), 7.73 (m, 1H), 7.81 (dd, J=1.2, 4.8 Hz, 1H), 8.11 (m, 2H), 8.32 (d, J=2.6 Hz, 1H), 8.64 (d, J=2.8 Hz, 1H); EIMS: 565 (M+1). Anal. (C28H25ClN4O5S) C, H, N.

Provenance & Evidence