1-(Thien-2-ylcarbonyl)piperazine → 6-Fluoro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile

Participants

Reaction Steps

This compound was prepared from 4-chloro-6-fluoro-2-oxo-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (96) and piperazin-1-yl-thiophene-2-yl-methanone according to general procedure E to yield 4.85 g (79%) of 6-fluoro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (98) as yellow solids. MP 244° C.; 1H-NMR (DMSO-d6): δ 3.72 (m, 4H), 3.91 (m, 4H), 7.16 (dd, J=3.6, 4.8 Hz, 1H), 7.49 (d, J=3.6 Hz, 1H), 7.80 (d, J=5.2 Hz, 1H), 8.05 (dd, J=2.8, 7.2 Hz, 1H), 8.70 (d, J=2.8 Hz, 1H); EIMS: 384 (M+1).

Provenance & Evidence