Benzyl Bromide → 1-Benzyl-6-fluoro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile

Participants

Reaction Steps

This compound was prepared from 6-fluoro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (98) and benzyl bromide according to General Procedure B. Yield 317 mg (43%), MP 173° C.; 1H-NMR (DMSO-d6): δ 3.73 (m, 4H), 3.92 (m, 4H), 5.53 (s, 2H), 7.22-7.30 (m, 6H), 7.49 (d, J=3.6 Hz, 1H), 7.80 (dd, J=1.2, 5.2 Hz, 1H), 8.16 (dd, J=2.8, 9.2 Hz, 1H), 8.77 (d, J=2.8 Hz, 1H); EIMS: 474 (M+1). Anal. (C25H20FN5O2S) C, H, N.

Provenance & Evidence