Benzyl Bromide → 1-Benzyl-6-chloro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazin 1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile

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Reaction Steps

This compound was prepared from 6-chloro-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (100) and benzyl bromide according to General Procedure B. Yield 184 mg (37%), MP 221° C.; 1H-NMR (DMSO-d6): 3.75 (m, 4H), 3.92 (m, 4H), 5.51 (s, 2H), 7.15-7.30 (m, 6H), 7.50 (d, J=3.6 Hz, 1H), 7.81(d, J=5.2 Hz, 1H), 8.32 (d, J=2.4 Hz, 1H), 8.75 (d, J=2.4 Hz, 1H); EIMS: 490 (M+1). Anal. (C25H20ClN5O2S) C, H, N.

Provenance & Evidence