Benzyl Bromide → 1-Benzyl-6-chloro-4-[4-(furan-2-carbonyl)-piperazin 1-yl]-2-oxo-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile

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Reaction Steps

This compound was prepared from 6-chloro-2-oxo-4-[4-(furan-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (101) and benzyl bromide according to General Procedure B. Yield 223 mg (31%), MP 196° C.; 1H-NMR (DMSO-d6): δ 3.75 (m, 4H), 3.94 (m, 4H), 5.51 (s, 2H), 6.66 (dd, J=1.6, 3.6 Hz, 1H), 7.09 (d, J=3.2 Hz, 1H), 7.22-7.28 (m, 5H), 7.89 (d, J=1.6 Hz, 1H), 8.32 (d, J=2.4 Hz, 1H), 8.76 (d, J=2.4 Hz, 1H); EIMS: 474 (M+1). Anal. (C25H20ClN5O3) C, H, N.

Provenance & Evidence