反应详情

This compound was prepared from 6-chloro-2-oxo-4-[4-(furan-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (101) and 3-fluorobenzyl bromide according to General Procedure B. Yield 113 mg (15%), MP 134° C.; 1H-NMR (DMSO-d6): δ 3.75 (m, 4H), 3.95 (m, 4H), 5.51 (s, 2H), 6.66 (dd, J=1.6, 3.2, Hz, 1H), 7.06-7.10 (m, 4H), 7.33 (m, 1H), 7.89 (d, J=2.0 Hz, 1H), 8.33 (dd, J=2.4 Hz, 1H), 8.75 (d, J=2.4 Hz, 1H); EIMS: 492 (M+1). Anal. (C25H19ClFN5O3) C, H, N.