3-Fluorobenzyl bromide → HCID 11443793, compound

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Reaction Steps

This compound was prepared from 2-oxo-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-[1,6]-naphthyridin-3-carboxylic acid ethyl ester (121) and 3-fluorobenzyl bromide according to General Procedure B. Yield 113 mg (22%), MP 135° C.; 1H-NMR (DMSO-d6): δ 1.28 (t, J=7.2 Hz, 3H), 3.22 (m, 4H), 3.92 (m, 4H), 4.32 (q, J=7.2 Hz, 2H), 5.44 (s, 2H), 6.98 (d, J=7.6 Hz, 1H), 7.10 (m, 2H), 7.16 (dd, J=3.6, 4.8 Hz, 1H), 7.34 (m, 2H), 7.47 (dd, J=1.2, 3.6 Hz, 1H), 7.80 (dd, J=1.2, 4.8 Hz, 1H), 8.56 (d, J=6.0 Hz, 1H), 9.09 (s, 1H); EIMS: 521 (M+1). Anal. (C27H25FN4O4S) C, H, N.

Provenance & Evidence