Methanol → HCID 22287095, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (6-{2-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2]dioxaborinan-4-yl)-acetic acid tert-butyl ester (5 g, 0.007 mol), water (200 ml), methanol (200 ml) and calcium oxide (5.0 g, 0.09 mol) was stirred at 50-60° C. for 10 hours. After filtering the reaction mixture, the resulting clear filtrate was concentrated to about 150 ml and washed with methyl tert-butyl ether (50 ml). The aqueous layer was evaporated and the solid obtained was dissolved in THF (50 ml). The solution was filtered and concentrated to yield [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, 1H-Pyrrole-1-heptanoic acid hemicalcium salt.

Provenance & Evidence