3-(3-Cyanophenyl)-2-(pyrrolidin-2-yl)-propionic acid methyl ester → 2-[1-[3-(Tert-butyloxycarbonylaminomethyl)biphenyl-4-carbonyl]-pyrrolidin-2-yl]-3-(3-cyanophenyl)-propionic acid methyl ester

Participants

Reaction Steps

3-(tert-Butyloxycarbonylaminomethyl)biphenyl-4-carboxylic acid (1.15 g, 3.5 mmol) and 3-(3-cyanophenyl)-2-(pyrrolidin-2-yl)-propionic acid methyl ester (0.91 g, 3.5 mmol) are coupled as described in EXAMPLE 1B to give the title compound (1.22 g, 2.8 mmol). 1H NMR (CDCl3, 300 MHz) □ 7.63-7.25(m, 12H), 4.85-4.70(two m, 1H), 4.48(m, 1H), 4.38(br.s, 2H), 3.80-3.71(m, 1H), 3.68, 3.62(two s, 3H), 3.63-3.40(m, 2H), 3.21-3.10(m, 1H), 2.90-2.78(m, 1H), 2.20-2.05(m, 1H), 2.02-1.65(m, 3H), 1.45(s, 9H).

Provenance & Evidence