HCID 136347716, compound → HCID 136347714, compound

Participants

Reaction Steps

4-Hydroxy-3-(2-{1-[4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzoyl]pyrrolidin-2-(R)-yl}-vinyl)benzamidine trifluoroacetate (0.0065 g, 0.01198 mmol) in MeOH (10 mL) and 5% Pd/C (catalytic amt.) is hydrogenated using a balloon filled with H2 gas for 4 h. The reaction is filtered, evaporated and the residue is diluted with H2O (10 mL). The aqueous solution is lyopholized to give the title compound as a white solid (0.0033 g, 0.00606 mmol). 1H NMR (DMSO-d6, 300 MHz) 8.97(s, 2H), 8.60(s, 2H), 7.93-7.26(m, 8H), 6.93(d, 1H), 6.42(d, 1H), 4.15(m, 1H), 3.61-3.35(m, 1H), 2.70-2.51(m, 2H), 2.45-1.98(m, 4H), 1.93-1.55(m, 3H). MS m/z: [M+H]+=431.

Provenance & Evidence