Ethylene Oxide → HCID 73100323, compound

HRID 901472Notes

Reaction equation

HRID 901472 reaction equation
[Cl:1][CH:2]([CH3:27])[CH:3]([NH:15][C:16]([CH:18]1[CH2:22][C:21]([F:26])([CH2:23][CH2:24][CH3:25])[CH2:20][NH:19]1)=[O:17])[CH:4]1[CH:9]([OH:10])[CH:8]([OH:11])[CH:7]([OH:12])[CH:6]([S:13][CH3:14])[O:5]1.[CH2:28]1[O:30][CH2:29]1>CO>[Cl:1][CH:2]([CH3:27])[CH:3]([NH:15][C:16]([CH:18]1[CH2:22][C:21]([F:26])([CH2:23][CH2:24][CH3:25])[CH2:20][N:19]1[CH2:28][CH2:29][OH:30])=[O:17])[CH:4]1[CH:9]([OH:10])[CH:8]([OH:11])[CH:7]([OH:12])[CH:6]([S:13][CH3:14])[O:5]1

Participants

4

Reactant 2

HCID 6354Ethylene OxideHCID 11362402HCID 11362402, compound

Product 1

HCID 73100323HCID 73100323, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Fluoro-4-propyl-pyrrolidine-2-carboxylic acid [2-chloro-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide 18a (Example 32) was treated with ethylene oxide in methanol as detailed in scheme 19 to furnish the title compound. MS (ESPOS): 473.3 [M+H]+.

Sources & evidence

ORD record
ord-f2d0377cf5144bf4901efb61886420a5
Source dataset
uspto-grants-2008_04
Patent number
US07361743B2

Reaction notes

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