反应详情

A mixture of 3-(chlorosulfonyl)benzoic acid (2.00 g) and dichloromethane (20 ml) under nitrogen at 0° was treated with cyclohexylamine (3.63 ml) and the mixture was stirred at 0° for 0.5 h. The solvent was evaporated in vacuo and the residue was treated with 1M potassium hydrogen sulfate solution (50 ml) and extracted with EtOAc (3×50 ml). The combined extracts were dried (Na2SO4) and the solvent evaporated in vacuo to give the title compound (2.28 g). LCMS RT=3.16 min, ES+ve 284 (MH)+.

1. customThe solvent was evaporated in vacuo
2. additionthe residue was treated with 1M potassium hydrogen sulfate solution (50 ml)
3. extractionextracted with EtOAc (3×50 ml)
4. dry with materialThe combined extracts were dried (Na2SO4)
5. customthe solvent evaporated in vacuo